geroscience

Open-source computational infrastructure for understanding, measuring and modeling biological aging.

🧬♻️ An AI-native, build-in-public compounding loop for aging science: falsifiable question → open data → public verifier → honest write-up → share → compound. No wet lab required.

Interactive force graph tracing diseases back to their root causes in the Hallmarks of Aging

Research checklists for published hiPSC maintenance, dual-SMAD, and GiWi protocols, with range checks and sterile gates.

Balanced optimal transport for cell-state snapshots, with auditable couplings and synthetic ambiguity benchmarks.

An agentic research project to collect, document, and track progress in longevity science

Why do dogs age so fast, and can AI help change it? A source-cited, cross-model-verified dossier: AlphaFold, IBM MAMMAL (with a video fact-check), AI for dogs & wolves, ageing biology, interventions, and ranked research paths. CC BY 4.0.

Dog aging and longevity research: cohorts, trials, drug programs, data, tools and papers. Companion dogs as the fastest route to human geroscience.

Offline gravimetric flow analysis, independent-repeat uncertainty and drift diagnostics for research pumps.

Group-aware baselines, leakage checks and reproducible reports for regenerative-medicine feature tables.

Closed-loop planner for in-vitro media factors. Expected improvement versus random search on a synthetic differentiation surface.

Source-traceable organoid mask measurement: object-level morphology, grouped instance agreement, frozen splits and hash-bound receipts. Geometry is not organoid health.

Open syringe-pump math, firmware, and a plunger carriage for in-vitro perfusion. The fluid path stays in the sterile syringe.

Conservative spherical oxygen transport for organoid research, with analytic and nonlinear numerical verification.

Brightfield colony and organoid morphology QC. Synthetic bake-off, retrainable logistic baseline. A contamination flag is triage, not a diagnosis.

Reproducible atlas mapping public compounds onto aging mechanisms with graded evidence (E0-E4) and Bemis-Murcko scaffold benchmark bake-off.

Control-gene module score for the published SenMayo gene set, with a size-matched random-set bake-off.

Local Docker workbench for computational biology research and agent tools.