Skip to content
View embryossa's full-sized avatar

Block or report embryossa

Block user

Prevent this user from interacting with your repositories and sending you notifications. Learn more about blocking users.

You must be logged in to block users.

Content in all repositories owned by your account will be closed.
Maximum 250 characters. Please don’t include any personal information such as legal names or email addresses. This note will only be visible to you.
Report abuse

Contact GitHub support about this user’s behavior. Learn more about reporting abuse.

Report abuse
embryossa/README.md

Serdj Sergeev

Embryology Lab Director · Computational Reproductive Medicine

I work at the intersection of clinical embryology and machine learning, developing predictive systems that translate the biological complexity of IVF into quantified, actionable probability estimates — from in vitro to in silico.

My core conviction is that the IVF laboratory already generates all the data needed to reason about outcomes far more rigorously than current practice allows. The challenge is not data collection but inference: building models that respect the sequential, stochastic nature of the embryological cascade, communicate uncertainty honestly, and remain interpretable to the clinicians who act on them.


My path into computational modelling came from clinical practice: years of working directly with IVF data made the gap between what the numbers contained and what decisions they actually informed increasingly difficult to ignore. The realization of my vision and my experience in the wet lab led to the conceptualization of transforming our IVF in vitro laboratory data into digital in silico analytics with AI — and finally grew into a new project built around an entirely new way of strategic thinking. The Digital Twin project is an attempt to close that gap — not by replacing clinical judgement, but by giving it a more rigorous quantitative foundation.


The central project is the IVF Digital Twin — a seven-layer probabilistic decision-support platform for IVF outcome prediction and patient stratification. Each layer addresses a distinct epistemic question, from stochastic simulation of ovarian response through neural ensemble prediction, unsupervised phenotype classification, diffusion-based laboratory forecasting, graph-based patient similarity reasoning, and Bayesian evidence fusion.

The platform is designed around a principle I call equifinality verification: the same clinical question is approached simultaneously from multiple independent methodological directions — parametric simulation, deep learning, generative modelling, graph neural networks — and the degree of convergence or divergence between their answers is itself diagnostically informative. When independent methods agree, that agreement is genuine corroboration. When they diverge, the divergence warrants clinical attention.

The most recent addition is the Total Reproductive Potential (TRP) framework — a strategic planning layer that extends single-cycle prediction to the couple's full reproductive horizon, modelling cumulative pregnancy probability, biological window closure risk, and AMH decline trajectories through Monte Carlo simulation conditioned on the patient's own KAT-calibrated baseline.


Python PyTorch


LinkedIn

Popular repositories Loading

  1. DNN DNN Public

    IVF KPIScore for clinical pregnansy prediction

    Jupyter Notebook 4 1

  2. DINO_KAN DINO_KAN Public

    DINO and KAN neural networks for image classification in IVF

    Python 4

  3. KAN-in-IVF KAN-in-IVF Public

    Introducing Kolmogorov-Arnold Networks (KANs) in IVF Treatment Prediction

    Jupyter Notebook 2

  4. Oocyte_Morphology_Analyzer Oocyte_Morphology_Analyzer Public

    A comprehensive deep learning pipeline for automated oocyte morphology analysis combining semantic segmentation with morphometric feature extraction and classification.

    Python 1

  5. embryossa embryossa Public

    Config files for my GitHub profile.

  6. Z-score_new_life Z-score_new_life Public

    Comprehensive Assessment of Pronuclear Morphological Pattern Prognostic Value Using Machine Learning Approaches in IVF Programs supplementary

    Jupyter Notebook