diff --git a/doc/api/module.md b/doc/api/module.md
index f05726286f0..f3707765a38 100644
--- a/doc/api/module.md
+++ b/doc/api/module.md
@@ -464,10 +464,12 @@ no-op, and the directory is not created if it is missing.
 
 ### Limitations of the compile cache
 
-Currently when using the compile cache with [V8 JavaScript code coverage][], the
-coverage being collected by V8 may be less precise in functions that are
-deserialized from the code cache. It's recommended to turn this off when
-running tests to generate precise coverage.
+V8 cannot collect block-level [V8 JavaScript code coverage][] for functions that
+are deserialized from the code cache. The compile cache is therefore disabled
+when coverage collection starts with the process, through
+[`NODE_V8_COVERAGE=dir`][] or [`--experimental-test-coverage`][]. Coverage that
+is started later, for example through the inspector, may be less precise in
+functions that were already deserialized from the code cache.
 
 Compilation cache generated by one version of Node.js can not be reused by a different
 version of Node.js. Cache generated by different versions of Node.js will be stored
@@ -525,7 +527,8 @@ The following constants are returned as the `status` field in the object returne
     <td><code>DISABLED</code></td>
     <td>
       Node.js cannot enable the compile cache because the environment variable
-      <code>NODE_DISABLE_COMPILE_CACHE=1</code> has been set.
+      <code>NODE_DISABLE_COMPILE_CACHE=1</code> has been set, or because V8
+      coverage is being collected.
     </td>
   </tr>
 </table>
@@ -2111,6 +2114,7 @@ returned object contains the following keys:
 [V8 code cache]: https://v8.dev/blog/code-caching-for-devs
 [`"exports"`]: packages.md#exports
 [`--enable-source-maps`]: cli.md#--enable-source-maps
+[`--experimental-test-coverage`]: cli.md#--experimental-test-coverage
 [`--import`]: cli.md#--importmodule
 [`--require`]: cli.md#-r---require-module
 [`NODE_COMPILE_CACHE=dir`]: cli.md#node_compile_cachedir
diff --git a/src/compile_cache.h b/src/compile_cache.h
index 527f72f33d4..25071de4cce 100644
--- a/src/compile_cache.h
+++ b/src/compile_cache.h
@@ -47,7 +47,7 @@ struct CompileCacheEntry {
   V(FAILED)          /* Failed to enable the cache */                          \
   V(ENABLED)         /* Was not enabled before, and now enabled. */            \
   V(ALREADY_ENABLED) /* Was already enabled. */                                \
-  V(DISABLED)        /* Has been disabled by NODE_DISABLE_COMPILE_CACHE. */
+  V(DISABLED)        /* Disabled by the environment or by V8 coverage. */
 
 enum class CompileCacheEnableStatus : uint8_t {
 #define V(status) status,
diff --git a/src/env.cc b/src/env.cc
index c30b6e2f504..426b7375679 100644
--- a/src/env.cc
+++ b/src/env.cc
@@ -1398,8 +1398,16 @@ CompileCacheEnableResult Environment::EnableCompileCache(
   std::string disable_env;
   if (credentials::SafeGetenv(
           "NODE_DISABLE_COMPILE_CACHE", &disable_env, this)) {
-    result.status = CompileCacheEnableStatus::DISABLED;
     result.message = "Disabled by NODE_DISABLE_COMPILE_CACHE";
+  }
+#if HAVE_INSPECTOR
+  // V8 cannot collect block coverage for functions deserialized from the cache.
+  if (result.message.empty() && coverage_connection() != nullptr) {
+    result.message = "Disabled because V8 coverage is being collected";
+  }
+#endif  // HAVE_INSPECTOR
+  if (!result.message.empty()) {
+    result.status = CompileCacheEnableStatus::DISABLED;
     Debug(this,
           DebugCategory::COMPILE_CACHE,
           "[compile cache] %s.\n",
diff --git a/test/parallel/test-compile-cache-api-env.js b/test/parallel/test-compile-cache-api-env.js
index 197f1495a88..aa7937df92a 100644
--- a/test/parallel/test-compile-cache-api-env.js
+++ b/test/parallel/test-compile-cache-api-env.js
@@ -10,6 +10,9 @@ const fixtures = require('../common/fixtures');
 const tmpdir = require('../common/tmpdir');
 const fs = require('fs');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 {
   // Test that it works with non-existent directory.
   tmpdir.refresh();
diff --git a/test/parallel/test-compile-cache-api-flush.js b/test/parallel/test-compile-cache-api-flush.js
index 7e66b1fee10..00aee0cd0a0 100644
--- a/test/parallel/test-compile-cache-api-flush.js
+++ b/test/parallel/test-compile-cache-api-flush.js
@@ -8,6 +8,9 @@ const assert = require('assert');
 const tmpdir = require('../common/tmpdir');
 const fixtures = require('../common/fixtures');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 {
   // Test that it works with non-existent directory.
   tmpdir.refresh();
diff --git a/test/parallel/test-compile-cache-api-options-portable-env.js b/test/parallel/test-compile-cache-api-options-portable-env.js
index 5586e3e8404..9922f5f80ed 100644
--- a/test/parallel/test-compile-cache-api-options-portable-env.js
+++ b/test/parallel/test-compile-cache-api-options-portable-env.js
@@ -11,6 +11,9 @@ const tmpdir = require('../common/tmpdir');
 const fs = require('fs');
 const path = require('path');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 const wrapper = fixtures.path('compile-cache-wrapper-options.js');
 tmpdir.refresh();
 
diff --git a/test/parallel/test-compile-cache-api-portable.js b/test/parallel/test-compile-cache-api-portable.js
index 620b3bdce87..f29826d469a 100644
--- a/test/parallel/test-compile-cache-api-portable.js
+++ b/test/parallel/test-compile-cache-api-portable.js
@@ -11,6 +11,9 @@ const tmpdir = require('../common/tmpdir');
 const path = require('path');
 const fixtures = require('../common/fixtures');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 tmpdir.refresh();
 const workDir = path.join(tmpdir.path, 'work');
 const cacheRel = '.compile_cache_dir';
diff --git a/test/parallel/test-compile-cache-api-readonly.js b/test/parallel/test-compile-cache-api-readonly.js
index 8ac0248a4d5..7512c847a08 100644
--- a/test/parallel/test-compile-cache-api-readonly.js
+++ b/test/parallel/test-compile-cache-api-readonly.js
@@ -11,6 +11,9 @@ const path = require('path');
 const tmpdir = require('../common/tmpdir');
 const fixtures = require('../common/fixtures');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 tmpdir.refresh();
 const wrapper = fixtures.path('compile-cache-wrapper-options.js');
 const target = path.join(tmpdir.path, 'target.js');
diff --git a/test/parallel/test-compile-cache-api-success.js b/test/parallel/test-compile-cache-api-success.js
index 2d4d94fd6e9..10b5dc813c2 100644
--- a/test/parallel/test-compile-cache-api-success.js
+++ b/test/parallel/test-compile-cache-api-success.js
@@ -10,6 +10,9 @@ const tmpdir = require('../common/tmpdir');
 const fs = require('fs');
 const path = require('path');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 {
   // Test that it works with non-existent directory.
   tmpdir.refresh();
diff --git a/test/parallel/test-compile-cache-api-tmpdir.js b/test/parallel/test-compile-cache-api-tmpdir.js
index e676893b01f..0353aa716af 100644
--- a/test/parallel/test-compile-cache-api-tmpdir.js
+++ b/test/parallel/test-compile-cache-api-tmpdir.js
@@ -11,6 +11,9 @@ const tmpdir = require('../common/tmpdir');
 const fs = require('fs');
 const path = require('path');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 {
   // Test that it works with non-existent directory.
   tmpdir.refresh();
diff --git a/test/parallel/test-compile-cache-bad-syntax.js b/test/parallel/test-compile-cache-bad-syntax.js
index 63f6374b2c3..213d295b4a0 100644
--- a/test/parallel/test-compile-cache-bad-syntax.js
+++ b/test/parallel/test-compile-cache-bad-syntax.js
@@ -10,6 +10,9 @@ const assert = require('assert');
 const fs = require('fs');
 const path = require('path');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 {
   // Test that it throws if the script fails to parse, and no cache is created.
   tmpdir.refresh();
diff --git a/test/parallel/test-compile-cache-coverage.js b/test/parallel/test-compile-cache-coverage.js
new file mode 100644
index 00000000000..f2f5e9e2f77
--- /dev/null
+++ b/test/parallel/test-compile-cache-coverage.js
@@ -0,0 +1,45 @@
+'use strict';
+
+const common = require('../common');
+common.skipIfInspectorDisabled();
+
+const { spawnSyncAndAssert } = require('../common/child_process');
+const assert = require('assert');
+const fixtures = require('../common/fixtures');
+const fs = require('fs');
+const tmpdir = require('../common/tmpdir');
+
+tmpdir.refresh();
+const cacheDir = tmpdir.resolve('compile_cache');
+const env = {
+  ...process.env,
+  NODE_DEBUG_NATIVE: 'COMPILE_CACHE',
+  NODE_V8_COVERAGE: tmpdir.resolve('coverage'),
+};
+
+spawnSyncAndAssert(
+  process.execPath,
+  [fixtures.path('empty.js')],
+  { env: { ...env, NODE_COMPILE_CACHE: cacheDir }, cwd: tmpdir.path },
+  { stderr: /Disabled because V8 coverage is being collected/ });
+assert(!fs.existsSync(cacheDir));
+
+spawnSyncAndAssert(
+  process.execPath,
+  ['-r', fixtures.path('compile-cache-wrapper.js'), fixtures.path('empty.js')],
+  {
+    env: {
+      ...env,
+      NODE_COMPILE_CACHE: undefined,
+      NODE_TEST_COMPILE_CACHE_DIR: cacheDir,
+    },
+    cwd: tmpdir.path,
+  },
+  {
+    stdout(output) {
+      assert.match(output, /Compile cache already disabled/);
+      assert.match(output, /dir after enableCompileCache: undefined/);
+    },
+    stderr: /Disabled because V8 coverage is being collected/,
+  });
+assert(!fs.existsSync(cacheDir));
diff --git a/test/parallel/test-compile-cache-dynamic-import.js b/test/parallel/test-compile-cache-dynamic-import.js
index 01731dc6822..d7b1daf57dc 100644
--- a/test/parallel/test-compile-cache-dynamic-import.js
+++ b/test/parallel/test-compile-cache-dynamic-import.js
@@ -8,6 +8,9 @@ const assert = require('assert');
 const tmpdir = require('../common/tmpdir');
 const fixtures = require('../common/fixtures');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 {
   tmpdir.refresh();
   const dir = tmpdir.resolve('.compile_cache_dir');
diff --git a/test/parallel/test-compile-cache-esm.js b/test/parallel/test-compile-cache-esm.js
index 963de8bcaba..0df4ba6a737 100644
--- a/test/parallel/test-compile-cache-esm.js
+++ b/test/parallel/test-compile-cache-esm.js
@@ -8,6 +8,9 @@ const assert = require('assert');
 const tmpdir = require('../common/tmpdir');
 const fixtures = require('../common/fixtures');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 {
   tmpdir.refresh();
   const dir = tmpdir.resolve('.compile_cache_dir');
diff --git a/test/parallel/test-compile-cache-existing-directory.js b/test/parallel/test-compile-cache-existing-directory.js
index 0fc60f9544d..f4f51e7786a 100644
--- a/test/parallel/test-compile-cache-existing-directory.js
+++ b/test/parallel/test-compile-cache-existing-directory.js
@@ -9,6 +9,9 @@ const fs = require('fs');
 const fixtures = require('../common/fixtures');
 const tmpdir = require('../common/tmpdir');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 {
   tmpdir.refresh();
   const dir = tmpdir.resolve('.compile_cache_dir');
diff --git a/test/parallel/test-compile-cache-portable-esm.js b/test/parallel/test-compile-cache-portable-esm.js
index 18766b6810e..a536602f3cf 100644
--- a/test/parallel/test-compile-cache-portable-esm.js
+++ b/test/parallel/test-compile-cache-portable-esm.js
@@ -9,6 +9,9 @@ const tmpdir = require('../common/tmpdir');
 const fs = require('fs');
 const path = require('path');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 tmpdir.refresh();
 
 const workDir = path.join(tmpdir.path, 'work');
diff --git a/test/parallel/test-compile-cache-portable.js b/test/parallel/test-compile-cache-portable.js
index b5978b5b0c6..8ea7cf400d4 100644
--- a/test/parallel/test-compile-cache-portable.js
+++ b/test/parallel/test-compile-cache-portable.js
@@ -10,6 +10,9 @@ const fs = require('fs');
 const tmpdir = require('../common/tmpdir');
 const path = require('path');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 tmpdir.refresh();
 const workDir = path.join(tmpdir.path, 'work');
 const cacheRel = '.compile_cache_dir';
diff --git a/test/parallel/test-compile-cache-success.js b/test/parallel/test-compile-cache-success.js
index c02a6243286..ff834501e54 100644
--- a/test/parallel/test-compile-cache-success.js
+++ b/test/parallel/test-compile-cache-success.js
@@ -10,6 +10,9 @@ const tmpdir = require('../common/tmpdir');
 const fs = require('fs');
 const path = require('path');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 {
   // Test that it works with non-existent directory.
   tmpdir.refresh();
diff --git a/test/parallel/test-compile-cache-typescript-commonjs.js b/test/parallel/test-compile-cache-typescript-commonjs.js
index 60e86c3c0f9..925d9366992 100644
--- a/test/parallel/test-compile-cache-typescript-commonjs.js
+++ b/test/parallel/test-compile-cache-typescript-commonjs.js
@@ -11,6 +11,9 @@ const assert = require('assert');
 const tmpdir = require('../common/tmpdir');
 const fixtures = require('../common/fixtures');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 // Check cache for .ts files that would be run as CommonJS.
 {
   tmpdir.refresh();
diff --git a/test/parallel/test-compile-cache-typescript-esm.js b/test/parallel/test-compile-cache-typescript-esm.js
index 98473dbb2a5..05142a2a8e9 100644
--- a/test/parallel/test-compile-cache-typescript-esm.js
+++ b/test/parallel/test-compile-cache-typescript-esm.js
@@ -11,6 +11,9 @@ const assert = require('assert');
 const tmpdir = require('../common/tmpdir');
 const fixtures = require('../common/fixtures');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 // Check cache for .ts files that would be run as ESM.
 {
   tmpdir.refresh();
diff --git a/test/parallel/test-compile-cache-typescript-strip-sourcemaps.js b/test/parallel/test-compile-cache-typescript-strip-sourcemaps.js
index a6c95e432b7..8e7f9f31477 100644
--- a/test/parallel/test-compile-cache-typescript-strip-sourcemaps.js
+++ b/test/parallel/test-compile-cache-typescript-strip-sourcemaps.js
@@ -12,6 +12,9 @@ const assert = require('assert');
 const tmpdir = require('../common/tmpdir');
 const fixtures = require('../common/fixtures');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 tmpdir.refresh();
 const dir = tmpdir.resolve('.compile_cache_dir');
 const script = fixtures.path('typescript', 'ts', 'test-typescript.ts');
diff --git a/test/parallel/test-compile-cache-updated-file.js b/test/parallel/test-compile-cache-updated-file.js
index 68f20a6990c..60c126843f0 100644
--- a/test/parallel/test-compile-cache-updated-file.js
+++ b/test/parallel/test-compile-cache-updated-file.js
@@ -8,6 +8,9 @@ const assert = require('assert');
 const fs = require('fs');
 const tmpdir = require('../common/tmpdir');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 {
   tmpdir.refresh();
   const dir = tmpdir.resolve('.compile_cache_dir');
diff --git a/test/parallel/test-compile-cache-wasm.js b/test/parallel/test-compile-cache-wasm.js
index 278198378dd..ac84f096b00 100644
--- a/test/parallel/test-compile-cache-wasm.js
+++ b/test/parallel/test-compile-cache-wasm.js
@@ -8,6 +8,9 @@ const assert = require('assert');
 const tmpdir = require('../common/tmpdir');
 const fixtures = require('../common/fixtures');
 
+// The compile cache is disabled while V8 coverage is being collected.
+process.env.NODE_V8_COVERAGE = '';
+
 const script = fixtures.path('es-modules', 'test-wasm-js-string-builtins.mjs');
 
 // V8 only serializes optimized code, so a complete cache requires eager